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Article

Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells.

Nature genetics - 1 Sept 2022

Rouhani Foad J, Zou Xueqing, Danecek Petr, Badja Cherif, Amarante Tauanne Dias, Koh Gene, Wu Qianxin, Memari Yasin, Durbin Richard, Martincorena Inigo, Bassett Andrew R, Gaffney Daniel, Nik-Zainal Serena

Abstract excerpt

We explored human induced pluripotent stem cells (hiPSCs) derived from different tissues to gain insights into genomic integrity at single-nucleotide resolution. We used genome sequencing data from two large hiPSC repositories involving 696 hiPSCs and daughter subclones. We find ultraviolet light (UV)-related damage in ~72% of skin fibroblast-derived hiPSCs (F-hiPSCs), occasionally resulting in substantial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35953586
DOI: 10.1038/s41588-022-01147-3
PMCID: PMC9470532

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