Article

Somatic mutation landscape revealed by non-invasive iPSC derivation from urine cells

2026-04-14

Abstract excerpt

Somatic mutations that arise post-zygotically create genetic diversity among normal human cells and provide key insights into human development and aging. Fibroblast-derived induced pluripotent stem cells (iPSCs) have proved to be a useful system for disease modelling; however, due to their clonal nature, iPSC lines carry somatic mutations inherited from the founder cells, raising concerns about their genomic inte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b941d638-7c13-5ecc-8b37-cd3e1ec78590
DOI: 10.64898/2026.04.11.717904

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic mutation landscape revealed by non-invasive iPSC derivation from urine cellsDOI 10.64898/2026.04.11.717904Read

Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestrySemantic proximity Read

Insights into the mutational burden of human induced pluripotent stem cells using an integrative omics approachSemantic proximity Read

Common genetic variation drives molecular heterogeneity in human IPSCsSemantic proximity Read

Insights into the Mutational Burden of Human Induced Pluripotent Stem Cells from an Integrative Multi-Omics Approach.Semantic proximity Read

Prenatal Life is the Predominant Source of Somatic Mosaicism Across Tissues and AgingSemantic proximity Read

The Somatic Mosaicism across Human Tissues Network.Semantic proximity Read

Somatic mutations from pathogenesis to forensic medicine: opportunities, challenges, and future directions.Semantic proximity Read

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.Semantic proximity Read

Multi-organ analysis of low-level somatic mosaicism reveals stage- and tissue-specific mutational features in human developmentSemantic proximity Read

Temporal stability of human sperm mosaic mutations results in life-long threat of transmission to offspringSemantic proximity Read

Optical genome mapping identifies source-associated structural variant differences across early-passage human iPSCsSemantic proximity Read

Common genetic variation drives molecular heterogeneity in human iPSCs.Semantic proximity Read