Article

Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry

2025-10-29

Abstract excerpt

The role of somatic mutations in human development and disease is obscured by difficulties in characterizing mutations at the single cell level and identifying cell types carrying them. Here we analysed somatic genomes of clonal iPSC lines and of single-cells after whole-genome amplification (scWGA) by PTA and ResolveOme from skin fibroblasts, blood and urine of a live donor. Mutation burden and spectra converged...

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Literature Corpus work: 1ce8fd96-354a-5ed4-9885-b9ccbcf9f1ae
DOI: 10.1101/2025.10.28.685157

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