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Article

Culture-acquired genetic variation in human pluripotent stem cells: Twenty years on.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Dec 2024

Vales John P, Barbaric Ivana

Abstract excerpt

Genetic changes arising in human pluripotent stem cells (hPSC) upon culture may bestow unwanted or detrimental phenotypes to cells, thus potentially impacting on the applications of hPSCs for clinical use and basic research. In the 20 years since the first report of culture-acquired genetic aberrations in hPSCs, a characteristic spectrum of recurrent aberrations has emerged. The preponderance of such aberrations...

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Identifiers

PMID: 38873900
DOI: 10.1002/bies.202400062
PMCID: PMC11589660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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