Article
A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy.
Cell stem cell - 3 Apr 2025
Benvenisty Nissim, Draper Jonathan S, Gokhale Paul J, Healy Lyn, Hewitt Zoe, Hursh Deborah, Hodgson Adam, Ludwig Tenneille E, Mah Nancy, McClelland Sarah E, Mennecozzi Milena, Merkle Florian T, Mountford Joanne C, Pera Martin, Prigione Alessandro, Rodriguez Tristan A, Rossi Andrea, Rouhani Foad J, Saeb-Parsy Kourosh, Selfa Aspiroz Lucia, Shakiba Nika, Spits Claudia, Tonge Peter D, Barbaric Ivana
Abstract excerpt
Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.
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