Article

Low-heteroplasmy mitochondrial DNA mutations improve clonal reconstruction of human cells

2026-08-21

Abstract excerpt

Reconstructing clonal relationships among human cells is fundamental to understanding development, aging, and disease. Somatic mitochondrial DNA (mtDNA) mutations act as endogenous single-cell barcodes measurable alongside cell-state profiles, but lineage tracing has traditionally focused on high-heteroplasmy variants, which are easier to detect but few and potentially shaped by selection. Whether the more abundan...

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Literature Corpus work: 8c157267-33cf-5a57-984c-d22b15b8de88
DOI: 10.64898/2026.08.17.745291

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