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Article

Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility.

Nature protocols - 1 May 2023

Lareau Caleb A, Liu Vincent, Muus Christoph, Praktiknjo Samantha D, Nitsch Lena, Kautz Pauline, Sandor Katalin, Yin Yajie, Gutierrez Jacob C, Pelka Karin, Satpathy Ansuman T, Regev Aviv, Sankaran Vijay G, Ludwig Leif S

Abstract excerpt

Natural sequence variation within mitochondrial DNA (mtDNA) contributes to human phenotypes and may serve as natural genetic markers in human cells for clonal and lineage tracing. We recently developed a single-cell multi-omic approach, called 'mitochondrial single-cell assay for transposase-accessible chromatin with sequencing' (mtscATAC-seq), enabling concomitant high-throughput mtDNA genotyping and accessible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36792778
DOI: 10.1038/s41596-022-00795-3
PMCID: PMC10317201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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