Article

Artifacts in single-cell mitochondrial DNA mutation analyses misinform phylogenetic inference

2024-07-29

Abstract excerpt

Sequencing mitochondrial DNA (mtDNA) variants from single cells has resolved clonality and lineage in native human samples and clinical specimens. Prior work established that heteroplasmic mtDNA variants can be used to delineate clonality in hematopoiesis, but they have limited ability to reconstruct cellular phylogenies. However, a recent report by Weng et al . challenges the current paradigm by describing an un...

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Literature Corpus work: 57f7dc72-4386-5092-981f-b6c297f7f480
DOI: 10.1101/2024.07.28.605517

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