Article
Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling.
Nature biotechnology - 1 Apr 2021
Lareau Caleb A, Ludwig Leif S, Muus Christoph, Gohil Satyen H, Zhao Tongtong, Chiang Zachary, Pelka Karin, Verboon Jeffrey M, Luo Wendy, Christian Elena, Rosebrock Daniel, Getz Gad, Boland Genevieve M, Chen Fei, Buenrostro Jason D, Hacohen Nir, Wu Catherine J, Aryee Martin J, Regev Aviv, Sankaran Vijay G
Abstract excerpt
Natural mitochondrial DNA (mtDNA) mutations enable the inference of clonal relationships among cells. mtDNA can be profiled along with measures of cell state, but has not yet been combined with the massively parallel approaches needed to tackle the complexity of human tissue. Here, we introduce a high-throughput, droplet-based mitochondrial single-cell assay for transposase-accessible chromatin with sequencing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.