Article

Single-cell mitochondrial lineage tracing decodes fate decision and spatial clonal architecture in human hematopoietic organoids

2023-09-18

Abstract excerpt

The ability to perform lineage tracing at the single-cell level is critical to reconstructing dynamic transitions during cell differentiation. However, prospective tracing approaches inevitably encounter outstanding challenges including barcoding precision, barcode diversity, and detection efficiency, which can skew inferred lineage relationships. Human pluripotent stem cells (hPSCs) even face risks of DNA-damage-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3aa0c1a2-88b7-5a52-8a2d-e34991121227
DOI: 10.1101/2023.09.18.558215

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell mitochondrial lineage tracing decodes fate decision and spatial clonal architecture in human hematopoietic organoidsDOI 10.1101/2023.09.18.558215Read

Evolving strategies for lineage tracing: Genetic markers, synthetic barcodes, and natural variants.Semantic proximity Read

Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNASemantic proximity Read

Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humansSemantic proximity Read

Low-heteroplasmy mitochondrial DNA mutations improve clonal reconstruction of human cellsSemantic proximity Read

Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cellsSemantic proximity Read

Deciphering cell states and genealogies of human haematopoiesis.Semantic proximity Read

Mitochondrial clone tracing within spatially intact human tissuesSemantic proximity Read

Robustness and reliability of single-cell regulatory multi-omics with deep mitochondrial mutation profilingSemantic proximity Read

High-resolution retrospective single cell lineage tracing with mutable homopolymersSemantic proximity Read

Quantitative fate mapping: Reconstructing progenitor field dynamics via retrospective lineage barcodingSemantic proximity Read

Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespanSemantic proximity Read