Article

LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice

2023-09-18

Abstract excerpt

<h4>ABSTRACT</h4> The intricate etiology of type 1 diabetes mellitus (T1D), marked by a detrimental cross-talk between the immune system and insulin-producing β-cells, has impeded effective disease-modifying therapies. The discovery that pharmacological activation of the nuclear receptor LRH-1/NR5A2 can reverse hyperglycemia in mouse models of T1D by attenuating the autoimmune attack coupled to β-cell survival/re...

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Literature Corpus work: 898f3604-d4a6-526a-815a-04e469123329
DOI: 10.1101/2023.09.18.558230

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