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Article

12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice

2024-07-28

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells and involves an interplay between β cells and cells of the innate and adaptive immune systems. We investigated the therapeutic potential of targeting 12-lipoxygenase (12-LOX), an enzyme implicated in inflammatory pathways in β cells and macrophages, using a mouse model in which the endogenous mouse...

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Literature Corpus work
74c307db-031f-5572-b46f-eb4879428806
DOI
10.1101/2024.07.28.604986
Open publication

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12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement miceDOI 10.1101/2024.07.28.604986
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