Article

The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin producing pancreatic β-cells. Macrophages infiltrate islets early in T1D pathogenesis, preceding the influx of T- and B-lymphocytes. The integrated stress response (ISR), a cellular pathway activated during stress, coordinates adaptive changes in gene expression to maintain cell function and survival. To s...

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Literature Corpus work: 2347eab5-fc8e-5ff3-8ecb-97e69018bd19
DOI: 10.1101/2024.10.31.621343

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