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Article

Alpha cell inflammation during human pancreas aging and type 2 diabetes and its reversal by calorie restriction in mice

2025-06-09

Abstract excerpt

Aging increases risk for type 2 diabetes (T2D), partly through loss of beta cell identity and function driven by metabolic stress and islet inflammation. While calorie restriction (CR) promotes beta cell longevity in young animals, its impact on cellular aging and inflammatory burden in older individuals is unclear. Using SCENIC regulon and multiomic analyses, we find that aging human alpha cells adopt a coordinat...

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Identifiers and source

Literature Corpus work
a214bf19-0c06-567f-9f67-79851ca10177
DOI
10.1101/2025.06.04.657914
Open publication

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Alpha cell inflammation during human pancreas aging and type 2 diabetes and its reversal by calorie restriction in miceDOI 10.1101/2025.06.04.657914
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