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Redox Regulation of m 6 A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes

2023-02-16

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<h4>SUMMARY</h4> Type 1 Diabetes (T1D) is characterized by autoimmune-mediated destruction of insulin-producing β-cells. Several observations have renewed interest in the innate immune system as an initiator of the disease process against β-cells. Here, we show that N 6 -Methyladenosine (m 6 A) is an adaptive β-cell safeguard mechanism that accelerates mRNA decay of the 2’-5’-oligoadenylate synthetase (OAS) gen...

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Literature Corpus work: 2251c202-1cac-5713-8b3a-d2842e4cd5f1
DOI: 10.1101/2023.02.16.528701

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Redox Regulation of m <sup>6</sup> A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes

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