Article

Single Nucleus Multiome Analysis Reveals Early Inflammatory Response to High-Fat Diet in Mouse Pancreatic Islets

2025-04-01

Abstract excerpt

<h4>Summary</h4> In periods of sustained hyper-nutrition, pancreatic β-cells undergo functional compensation through transcriptional upregulation of gene programs driving insulin secretion. This adaptation is essential for maintaining systemic glucose homeostasis and metabolic health. Using single nuclei multiomics, we have mapped the early transcriptional compensation mechanisms in murine islets of Langerhans ex...

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Literature Corpus work: d08540a8-8792-551b-914d-ef6d7cc81ccf
DOI: 10.1101/2025.04.01.646568

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