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Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility

2025-10-07

Abstract excerpt

<h4>ABSTRACT</h4> Whereas most autoimmune diseases exhibit female predominance, type 1 diabetes (T1D) occurs more frequently in males after puberty, suggesting a role for sex hormones in disease modification. Because islet β cells actively shape local immune responses, we hypothesized that sex-specific islet responses to inflammation contribute to this disparity. Using transcriptomic and proteomic analyses of hum...

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Literature Corpus work
6c20b3aa-ed83-5b31-8d11-56037b190e32
DOI
10.1101/2025.10.06.680429
Open publication

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Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibilityDOI 10.1101/2025.10.06.680429
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