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Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes

8 Feb 2022

Abstract excerpt

BACKGROUNDPathophysiology of type 1 diabetes (T1D) is illustrated by pancreatic islet infiltration of inflammatory lymphocytes, including CD8+ T cells; however, the molecular factors mediating their recruitment remain unknown. We hypothesized that single-cell RNA-sequencing (scRNA-Seq) analysis of immune cell populations isolated from islets of NOD mice captured gene expression dynamics providing critical insight...

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PMID: 35133983
DOI: 10.1172/jci.insight.153136

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