LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype.

doi:10.1002/ctm2.70134

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Article

LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype.

Clinical and translational medicine - 1 Dec 2024

Cobo-Vuilleumier Nadia, Rodríguez-Fernandez Silvia, López-Noriega Livia, Lorenzo Petra I, Franco Jaime M, Lachaud Christian C, Vazquez Eugenia Martin, Legido Raquel Araujo, Dorronsoro Akaitz, López-Férnandez-Sobrino Raul, Fernández-Santos Beatriz, Serrano Carmen Espejo, Salas-Lloret Daniel, van Overbeek Nila, Ramos-Rodriguez Mireia, Mateo-Rodríguez Carmen, Hidalgo Lucia, Marin-Canas Sandra, Nano Rita, Arroba Ana I, Caro Antonio Campos, Vertegaal Alfred Co, Martin-Montalvo Alejandro, Martín Franz, Aguilar-Diosdado Manuel, Piemonti Lorenzo, Pasquali Lorenzo, Prieto Roman González, Sánchez Maria Isabel García, Eizirik Decio L, Martínez-Brocca Maria Asuncion, Vives-Pi Marta, Gauthier Benoit R

Abstract excerpt

BACKGROUND: The complex aetiology of type 1 diabetes (T1D), characterised by a detrimental cross-talk between the immune system and insulin-producing beta cells, has hindered the development of effective disease-modifying therapies. The discovery that the pharmacological activation of LRH-1/NR5A2 can reverse hyperglycaemia in mouse models of T1D by attenuating the autoimmune attack coupled to beta cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39702941
DOI: 10.1002/ctm2.70134
PMCID: PMC11659195

Genes

NR5A2
CD4

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