Article

Harnessing distinct tissue-resident immune niches <i>via</i> S100A9/TLR4 improves ketone, lipid, and glucose metabolism

2025-05-27

Abstract excerpt

Immunometabolism contributes to the development of metabolic diseases. Yet, how certain metabolic disorders, such as insulin deficiency (ID), influence immune cell function is poorly understood. Here, we observe that ID rearranges the immune landscape of the liver, causing a decrease in T cells and an increase in Kupffer cells, accompanied by a shift in the transcriptome and polarization of the latter. Treating ID...

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Identifiers and source

Literature Corpus work: 2698cfa1-93fc-5290-8fe2-41e6ba17b822
DOI: 10.1101/2025.05.21.655283

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