Article

Beta Cells Deficient for <i>Renalase</i> Counteract Autoimmunity by Shaping Natural Killer Cell Activity

2024-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 diabetes (T1D) arises from autoimmune-mediated destruction of insulin-producing pancreatic beta cells. Recent advancements in the technology of generating pancreatic beta cells from human pluripotent stem cells (SC-beta cells) have facilitated the exploration of cell replacement therapies for treating T1D. However, the persistent threat of autoimmunity poses a significant challenge to the...

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Literature Corpus work: cb41f657-7ce3-59fa-ab48-53ce76217644
DOI: 10.1101/2024.02.29.582816

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