Article

Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T cells

2022-05-12

Abstract excerpt

<h4>ABSTRACT</h4> IL-2 has been proposed to restore tolerance via regulatory T cell (Treg) expansion in autoimmunity, yet off-target effects necessitate identification of a combinatorial approach. We recently reported reduced levels of immunoregulatory insulin-like growth factor-1 (IGF1) during type 1 diabetes (T1D) progression. Thus, we hypothesized that IGF1 would synergize with IL-2 to expand Tregs. We observe...

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Literature Corpus work: e0f9648a-af6a-589f-803e-fa3c29949dfb
DOI: 10.1101/2022.05.12.491665

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