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Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells

14 Sept 2022

Abstract excerpt

IFNα is a key regulator of the dialogue between pancreatic β cells and the immune system in early type 1 diabetes (T1D). IFNα up-regulates HLA class I expression in human β cells, fostering autoantigen presentation to the immune system. We observed by bulk and single-cell RNA sequencing that exposure of human induced pluripotent-derived islet-like cells to IFNα induces expression of HLA class I and of other genes...

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PMID: 36103539
DOI: 10.1126/sciadv.abn5732

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