Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel

Abstract excerpt

<h4>ABSTRACT</h4> Hyperpolarization and cyclic-nucleotide (HCN) activated ion channels play a critical role in generating self-propagating action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage-gated ion channels, the HCN channels activate upon membrane hyperpolarization, but the structural mechanisms underlying this gating behavior remain unclear. Here, we present...

Topics

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• Amino Acid Motifs
• Amino Acid Sequence
• Cyclic Nucleotide-Gated Cation Channels
• Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
• Mutation
• Potassium Channels
• Sea Urchins
• Sequence Alignment

Identifiers and source

Literature Corpus work

897198c8-b18c-536d-a879-141ce76baf90

DOI

10.1101/2023.08.17.553623