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Article

Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation.

The Journal of general physiology - 1 May 2023

Wu Xiaoan, Cunningham Kevin P, Ramentol Rosamary, Perez Marta E, Larsson H Peter

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to the rhythmic firing of pacemaker neurons and cardiomyocytes. Mutations in HCN channels are associated with cardiac arrhythmia and epilepsy. HCN channels belong to the superfamily of voltage-gated K+ channels, most of which are activated by depolarization. HCN channels, however, are activated by hyperpolarization. The mechanism behind...

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Share to Cyclic Nucleotide-Gated Cation Channels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36752823
DOI: 10.1085/jgp.202213170
PMCID: PMC9948645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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