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Article

Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions.

American journal of physiology. Cell physiology - 1 Jan 2008

Au Ka-Wing, Siu Chung-Wah, Lau Chu-Pak, Tse Hung-Fat, Li Ronald A

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are responsible for the membrane pacemaker current that underlies the spontaneous generation of bioelectrical rhythms. However, their structure-function relationship is poorly understood. Previously, we identified several pore residues that influence HCN gating properties and proposed a pore-to-gate mechanism. Here, we systematically...

Topics

Amino Acid Sequence
Animals
Cadmium Chloride
Cyclic Nucleotide-Gated Cation Channels
Cysteine
Dithiothreitol
Ethyl Methanesulfonate
Female
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Ion Channel Gating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Membrane Potentials

Mice

Microinjections

Models, Molecular

Molecular Sequence Data

Mutation

Oocytes

Source

Identifiers

PMID: 17989208
DOI: 10.1152/ajpcell.00340.2007

Genes

HCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions.PMID 17989208Read ↗

Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation.Semantic proximity Read ↗

Identification of a surface charged residue in the S3-S4 linker of the pacemaker (HCN) channel that influences activation gating.Semantic proximity Read ↗

A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.Semantic proximity Read ↗

Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 ChannelSemantic proximity Read ↗

Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization.Semantic proximity Read ↗

A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating.Semantic proximity Read ↗

A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore.Semantic proximity Read ↗

A rare gain of function HCN4 gene mutation is responsible for inappropriate sinus tachycardia in a Spanish familySemantic proximity Read ↗

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A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish familySemantic proximity Read ↗

A rare HCN4 variant combined with sick sinus syndrome, left ventricular noncompaction, and complex congenital heart disease.Semantic proximity Read ↗

Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels.Semantic proximity Read ↗

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