Article

Structural basis for gating inhibition by the cytoplasmic domain in HCN1 channels

2025-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate rhythmic electrical activity in cardiac and neuronal tissues, with isoform-specific cAMP sensitivity remaining poorly understood. While HCN2 exhibits strong cAMP regulation, HCN1 shows minimal response. To investigate the structural basis of this divergence, we analyzed two engineered HCN1 variants using cryo-electron m...

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Literature Corpus work: e7e3c228-fddf-5960-8a3b-7a28a582feb9
DOI: 10.1101/2025.10.14.682313

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