Article

Structural dynamics determine voltage and pH gating in human voltage-gated proton channel

2021-08-26

Abstract excerpt

Voltage-gated ion channels are key players of electrical signaling in cells. As a unique subfamily, voltage-gated proton (Hv) channels are standalone voltage sensors without separate ion conductive pores. They are gated by both voltage and transmembrane proton gradient (i.e ΔpH), serving as acid extruders in most cells. Amongst their many functions, Hv channels are known to regulate the intracellular pH of human s...

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Literature Corpus work: 9e8c429f-5bc5-595d-87bc-12ad423ad742
DOI: 10.1101/2021.08.25.457625

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