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Article

Gating mechanism of hyperpolarization-activated HCN pacemaker channels.

Nature communications - 17 Mar 2020

Ramentol Rosamary, Perez Marta E, Larsson H Peter

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain, and mutations in HCN channels are linked to heart arrhythmia and epilepsy. HCN channels belong to the family of voltage-gated K+ (Kv) channels. However, why HCN channels are activated by hyperpolarization whereas Kv channels are activated by depolarization is not clear. Here we reverse...

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Identifiers

PMID: 32184399
DOI: 10.1038/s41467-020-15233-9
PMCID: PMC7078272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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