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Article

A negative-hydrated constriction zone is revealed in the active state of the Hv1 channel.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2026

Alvear-Arias Juan J, Basaez Dario, Carmona Emerson M, Galizia Luciano, Fernandez Miguel, Peña-Pichicoi Antonio, Ozu Marcelo, Jorquera Orlando, Latorre Ramón, Neely Alan, Garate Jose Antonio, Gonzalez Carlos

Abstract excerpt

The voltage-gated proton (Hv1) channel is crucial in regulating cellular pH, yet the mechanism underlying proton permeation remains controversial. A deeper understanding of the differences between the channel's active and resting states is essential for clarifying its conductive properties. In this study, we employ a combination of molecular dynamics simulations, site-directed mutagenesis, and...

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Identifiers

PMID: 42189973
DOI: 10.1073/pnas.2518376123
PMCID: PMC13229269

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