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Article

Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation.

The Journal of physiology - 1 Mar 2007

Ishii Takahiro M, Nakashima Noriyuki, Ohmori Harunori

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential regulators in rhythmic activity, membrane excitability and synaptic transmission. There are four subtypes in mammals (HCN1-4); HCN4 has the slowest activation kinetics and HCN1 the fastest. Although voltage gating originates with the voltage-dependent motion of the S4 segment, the different activation kinetics between HCN1 and HCN4...

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Source

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Identifiers

PMID: 17185333
DOI: 10.1113/jphysiol.2006.124297
PMCID: PMC2075410

Genes

HCN1
HCN4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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