Article

Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge

2019-10-02

Abstract excerpt

Human KCNH2 (hKCNH2, Ether-à-go-go (EAG)-Related Gene, hERG) are best known for their role in cardiac action potentials repolarization and have key roles in various pathologies. As other KCNH family members, hKCNH2 contains a unique intracellular complex crucial for channel function, consisting of an N-terminal eag domain and a C-terminal cyclic nucleotide-binding homology domain (CNBHD). Previous studies demonstr...

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Literature Corpus work: acff3bf0-c38d-509d-b83a-ba10912eedc3
DOI: 10.1101/790154

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