Article

Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel

2023-01-08

Abstract excerpt

Voltage gradient is a general physical cue that regulates diverse biological function through voltage-gated ion channels. How voltage sensing mediates ion flows remains unknown at the molecular level. Here, we report six conformations of the human Eag2 (hEag2) ranging from closed, pre-open, open, and pore dilation but non-conducting states captured by cryo-electron microscopy (cryo-EM). These multiple states illum...

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Literature Corpus work: 05a4e93d-6e7c-5f05-8156-f679c93424ab
DOI: 10.1101/2023.01.07.523124

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