Article

Conformational plasticity of human acid-sensing ion channel 1a

2024-12-12

Abstract excerpt

<h4>Summary</h4> Acid-sensing ion channels (ASICs) are typically activated by acidic environments and contribute to nociception and synaptic plasticity. ASIC1a is the most abundant subunit in the central nervous system and forms homomeric channels permeable to Na + and Ca 2+ , making it a compelling therapeutic target for acidotic pathologies including stroke and traumatic brain injury. However, a complete conf...

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Literature Corpus work: 51361bbd-f84f-5f51-a745-3c7cb83e680b
DOI: 10.1101/2024.12.11.628012

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