Article

An Allosteric Model for Electromechanical Coupling in Cardiac CNBD Channels

2025-08-01

Abstract excerpt

Ion channels in the cyclic nucleotide-binding domain (CNBD) family, including hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and human ether-à-go-go-related gene (hERG) channels, play pivotal roles in regulating cardiac action potentials. HCN channels are uniquely activated by hyperpolarization, rather than depolarization, a critical mechanism for controlling the involuntary pacemaker activity...

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Literature Corpus work: ab28eac8-0e38-5268-b3b2-5a36e2d7d0ce
DOI: 10.1101/2025.07.28.666606

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