HCN4 channels sense temperature and determine heart rate responses to heat.

doi:10.1038/s41467-025-57358-9

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Article

HCN4 channels sense temperature and determine heart rate responses to heat.

Nature communications - 1 Mar 2025

Wu Yuejin, Wang Qinchuan, Granger Jonathan, Reyes Gaido Oscar, Lopez-Cecetaite Gabriel, Aguilar Eric Nunez, Ludwig Andreas, Moroni Anna, Bianchet Mario A, Anderson Mark E

Abstract excerpt

The hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (HCN4) current increases due to cAMP binding and is well-recognized to contribute to adrenergically driven heart rate acceleration. HCN4 current also increases with heat by an unknown mechanism(s). We use thermodynamical and homology computational modeling, site-directed mutagenesis, and mouse models to identify a concise motif on the S4-S5...

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Topics

Animals
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Cyclic AMP
Heart Rate
Mice
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hot Temperature

HEK293 Cells

Potassium Channels

Ion Channel Gating

Amino Acid Motifs

Male

Mutagenesis, Site-Directed

Myocytes, Cardiac

Mice, Inbred C57BL

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40025061
DOI: 10.1038/s41467-025-57358-9
PMCID: PMC11873294

Genes

HCN4

Provenance

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