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Article

Disease insights from brain somatic mosaicism.

Experimental & molecular medicine - 1 Apr 2026

Chung Changuk, Nedunuri Rahul, Gleeson Joseph G

Abstract excerpt

Brain somatic mosaicism (BSM) refers to genome variation within brain cells that results from accumulated postzygotic mutations. These mutations can be used to understand cell lineage, molecular dynamics and disease processes. Unlike most other organs, brain cells are mostly fixed in position and not replaced throughout life. Thus, assessing mosaic variants (MVs) within the brain, including their spread and cell...

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PMID: 41951903
DOI: 10.1038/s12276-024-01331-x
PMCID: PMC13144381

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