Article

Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex

2023-11-07

Abstract excerpt

The mammalian cerebral cortex shows functional specialization into regions with distinct neuronal compositions, most strikingly in the human brain, but little is known in about how cellular lineages shape cortical regional variation and neuronal cell types during development. Here, we use somatic single nucleotide variants (sSNVs) to map lineages of neuronal sub-types and cortical regions. Early-occurring sSNVs ra...

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Literature Corpus work: 992e109e-6dab-5363-8295-2e2f9a6c3b20
DOI: 10.1101/2023.11.06.565899

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