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Backtracking Cell Phylogenies in the Human Brain with Somatic Mosaic Variants.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2025

Bizzotto Sara

Abstract excerpt

Somatic mosaic variants, and especially somatic single nucleotide variants (sSNVs), occur in progenitor cells in the developing human brain frequently enough to provide permanent, unique, and cumulative markers of cell divisions and clones. Here, we describe an experimental workflow to perform lineage studies in the human brain using somatic variants. The workflow consists in two major steps: (1) sSNV calling...

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Brain
Cell Lineage
Genome, Human
Mosaicism
Phylogeny
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Whole Genome Sequencing

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PMID: 39745642
DOI: 10.1007/978-1-0716-4310-5_10

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