Article
Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.
Cell reports - 25 Nov 2025
Viswanadham Vinayak V, Kim Sonia N, Caglayan Emre, Doan Ryan N, Dou Yanmei, Bizzotto Sara, Khoshkhoo Sattar, Huang August Yue, Yeh Rebecca, Chhouk Brian H, Truong Alex, Chappell Kathleen M, Beaudin Marc, Barton Alison, Akula Shyam K, Zhao Yifan, Rento Lariza, Lodato Michael, Szeto Ryan A, Ganz Javier, Li Pengpeng, Tsai Jessica W, Hill Robert Sean, Park Peter J, Walsh Christopher A
Abstract excerpt
The human cerebral cortex is specialized into regions, but little is known about how human cellular lineages shape cortical regional variation and neuronal cell-type distribution during development. Here, we map single-cell lineages of human cortical regions and neuronal subtypes using >1,000 somatic single-nucleotide variants (sSNVs) identified from deep bulk whole-genome sequencing and analyzed over 25 regions...
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