Article
Somatic Mosaicism of the Brain: The Functional Implications of Post-Zygotic Mutations to Neural Circuits.
The European journal of neuroscience - 1 Sept 2026
Al-Hakeem Maher Abdulrazzaq, Almajidi Yasir Qasim, Alshkarchy Samer Saleem, Kareem Ali Kamil, Rangaswamy Roopashree, Al-Khafaji Zahraa Khudhair, Nayak Priya Priyadarshini, Chennakesavulu Kattela, Sharma Renu, Kadhum Wesam R
Abstract excerpt
The human brain is a genomic mosaic shaped by post-zygotic mutations that accumulate from the earliest embryonic divisions through aging. This review synthesizes current evidence on the origins, detection, functional consequences and disease relevance of neural somatic mosaicism. We find that somatic variants-including single-nucleotide variants, copy-number variations, mobile element insertions, structural...
Read the complete abstract on PubMedTopics
- Mosaicism
- Humans
- Brain
- Mutation
- Animals