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Cohesin guides homology search during DNA repair via loops and sister chromatid linkages

2025-02-10

Abstract excerpt

Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequence to faithfully restore damaged DNA, yet how broken DNA ends find homologous sites in a genome containing billions of non-homologous bases remains unclear. Here, we introduce sister-pore-C, a high-resolution method fo...

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Literature Corpus work
863a33b5-8250-5781-9ee8-0f1ed2d24396
DOI
10.1101/2025.02.10.637359
Open publication

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Cohesin guides homology search during DNA repair via loops and sister chromatid linkagesDOI 10.1101/2025.02.10.637359
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