Article

The kleisin subunit controls the function of meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

2022-10-12

Abstract excerpt

The cohesin complex plays essential roles in chromosome segregation, 3D genome organisation, and DNA damage repair through its ability to modify DNA topology. In higher eukaryotes, meiotic chromosome function, and therefore fertility, requires cohesin complexes containing meiosis-specific kleisin subunits: REC8 and RAD21L in mammals and REC-8 and COH-3/4 in C. elegans . How these complexes perform the multiple fu...

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Literature Corpus work: b600164c-2c8b-5976-a785-0e1e498604b9
DOI: 10.1101/2022.10.12.511771

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