Article

Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes

2019-05-31

Abstract excerpt

The mammalian genome can be segmented into thousands of topologically associated domains (TADs) based on chromosome conformation capture studies, such as Hi-C. TADs have been proposed to act as insulated neighborhoods, spatially sequestering and insulating the enclosed genes and regulatory elements through chromatin looping and self-association. Recent results indicate that inter-TAD interactions can also occur, s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba3521f3-eb8e-585f-9827-7a687f0e1d2a
DOI: 10.1101/649335

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genesDOI 10.1101/649335Read

When TADs go bad: chromatin structure and nuclear organisation in human diseaseSemantic proximity Read

Cohesin loss eliminates all loop domains, leading to links among superenhancers and downregulation of nearby genesSemantic proximity Read

Stratification of TAD boundaries identified in reproducible Hi-C contact matrices reveals preferential insulation of super-enhancers by strong boundariesSemantic proximity Read

Spatial Genome Organization as a Framework for Somatic Alterations in Human CancerSemantic proximity Read

Heterogeneity and Intrinsic Variation in Spatial Genome OrganizationSemantic proximity Read

Chromatin accessibility classification of TAD boundaries discloses new architectural proteinsSemantic proximity Read

Topologically associating domain (TAD) boundaries stable across diverse cell types are evolutionarily constrained and enriched for heritabilitySemantic proximity Read

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and functionSemantic proximity Read

Topologically associating domain boundaries are required for normal genome function.Semantic proximity Read

Gene structure heterogeneity drives transcription noise within human chromosomesSemantic proximity Read

Universal dynamics of cohesin-mediated loop extrusionSemantic proximity Read

Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability.Semantic proximity Read