Article

Cohesin loss eliminates all loop domains, leading to links among superenhancers and downregulation of nearby genes

2017-05-18

Abstract excerpt

<h4>SUMMARY</h4> The human genome folds to create thousands of intervals, called “contact domains,” that exhibit enhanced contact frequency within themselves. “Loop domains” form because of tethering between two loci - almost always bound by CTCF and cohesin – lying on the same chromosome. “Compartment domains” form when genomic intervals with similar histone marks co-segregate. Here, we explore the effects of de...

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Literature Corpus work: 86e6f57d-e491-52b8-a8d7-c20a4c2c0079
DOI: 10.1101/139782

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