Article
Cohesin organization, dynamics, and subdomain functions revealed by genetic suppressor screening.
Proceedings of the Japan Academy. Series B, Physical and biological sciences - 1 Jan 2023
Xu Xingya, Yanagida Mitsuhiro
Abstract excerpt
Cohesin is a heteropentameric protein complex that contributes to various aspects of chromosome structure and function, such as sister chromatid cohesion, genome compaction, and DNA damage response. Previous studies have provided abundant information on architecture and regional structures of the cohesin complex, but the configuration and structural dynamics of the whole cohesin complex are still largely unknown,...
Topics
- Chromosomal Proteins, Non-Histone
- Cell Cycle Proteins
- DNA
- Mutation
- Cohesins