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Article

Cohesin regulates homology search during recombinational DNA repair.

Nature cell biology - 1 Nov 2021

Piazza Aurèle, Bordelet Hélène, Dumont Agnès, Thierry Agnès, Savocco Jérôme, Girard Fabien, Koszul Romain

Abstract excerpt

Homologous recombination repairs DNA double-strand breaks (DSB) using an intact dsDNA molecule as a template. It entails a homology search step, carried out along a conserved RecA/Rad51-ssDNA filament assembled on each DSB end. Whether, how and to what extent a DSB impacts chromatin folding, and how this (re)organization in turns influences the homology search process, remain ill-defined. Here we characterize two...

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Source

Identifiers

PMID: 34750581
DOI: 10.1038/s41556-021-00783-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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