Conformational asymmetry of replicated human chromosomes

Abstract excerpt

DNA replication creates two sister chromatids that must acquire specific three-dimensional conformations to support genome function and stability. This organization is largely mediated by cohesin complexes, which extrude intra-chromosomal loops and link two chromatids, thus forming “chromatid cohesion”. Although sister chromatids are genetically identical, the replication process is intrinsically asymmetric: each...

Topics

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• Gene Dosage
• Genetic Variation
• Genome
• Histones
• Mutation
• Protein Processing, Post-Translational

Identifiers and source

Literature Corpus work

cb6e07de-ddf6-5c2b-ab4d-77384812d086

DOI

10.1101/2025.07.09.663929