Article

Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase

2023-01-12

Abstract excerpt

Genetic information is stored in linear DNA molecules, which fold extensively inside cells. DNA replication along the folded template path yields two sister chromatids that initially occupy the same nuclear region in a highly intertwined arrangement. Dividing cells must disentangle and condense the sister chromatids into separate bodies such that a microtubule-based spindle can move them to opposite poles. While t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3fcbaea9-787f-5d36-94b9-de1c3e3d49b8
DOI: 10.1101/2023.01.12.523718

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phaseDOI 10.1101/2023.01.12.523718Read

Condensin complexes: understanding loop extrusion one conformational change at a time.Semantic proximity Read

Condensins promote chromosome recoiling during early anaphase to complete sister chromatid separation.Semantic proximity Read

AT-hook-dependent DNA loop extrusion by STAG1 drives 3D genome foldingSemantic proximity Read

Controlling mechanism of the Scc2-cohesin interaction to restrict peri-centromeric DNA loop expansion and facilitate mitotic chromosome segregationSemantic proximity Read

A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping.Semantic proximity Read

Universal dynamics of cohesin-mediated loop extrusionSemantic proximity Read

Mitotic chromosome compaction via active loop extrusionSemantic proximity Read

Nanoscale 3D DNA tracing in single human cells visualizes loop extrusion directly in situSemantic proximity Read

Dynamics of sister chromatid resolution during cell cycle progressionSemantic proximity Read

SMC complexes and topoisomerase II work together so that sister chromatids can work apart.Semantic proximity Read

A conserved activity for cohesin in bridging DNA moleculesSemantic proximity Read

Cohesin prevents local mixing of condensed euchromatic domains in living human cellsSemantic proximity Read