Article

Non-canonical secondary structures arising from non-B-DNA motifs are determinants of mutagenesis

2017-06-06

Abstract excerpt

<h4>Summary</h4> Somatic mutations show variation in density across cancer genomes. Previous studies have shown that chromatin organization and replication time domains are correlated with and thus predictive of this variation 1,2,3,4,5 . Here, we analyse 1,809 whole-genome sequences from nine cancer types 6,7,8 to show that a subset of repetitive DNA sequences called non-B motifs that predict non-canonical sec...

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Literature Corpus work: 86122649-0905-56f6-ae25-a49b54fab057
DOI: 10.1101/146621

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